Xue-Ru Wu Selected Research

Uromodulin

1/2022	The kidney protects against sepsis by producing systemic uromodulin.
1/2018	Uromodulin deficiency alters tubular injury and interstitial inflammation but not fibrosis in experimental obstructive nephropathy.
1/2018	Tamm-Horsfall protein/uromodulin deficiency elicits tubular compensatory responses leading to hypertension and hyperuricemia.
1/2017	Point mutation in D8C domain of Tamm-Horsfall protein/uromodulin in transgenic mice causes progressive renal damage and hyperuricemia.
4/2013	Tamm-Horsfall protein translocates to the basolateral domain of thick ascending limbs, interstitium, and circulation during recovery from acute kidney injury.
3/2012	Uromodulin in kidney injury: an instigator, bystander, or protector?
8/2008	Tamm-Horsfall protein protects the kidney from ischemic injury by decreasing inflammation and altering TLR4 expression.
12/2007	Renal calcinosis and stone formation in mice lacking osteopontin, Tamm-Horsfall protein, or both.
1/2004	Variation of high mannose chains of Tamm-Horsfall glycoprotein confers differential binding to type 1-fimbriated Escherichia coli.
4/2002	Isolation of mouse THP gene promoter and demonstration of its kidney-specific activity in transgenic mice.

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Xue-Ru Wu Research Topics

Disease

39	Urinary Bladder Neoplasms (Bladder Cancer) 01/2022 - 07/2002
35	Neoplasms (Cancer) 01/2021 - 07/2002
14	Carcinogenesis 01/2022 - 05/2005
14	Carcinoma (Carcinomatosis) 03/2016 - 07/2002
7	Inflammation (Inflammations) 01/2018 - 07/2008
6	Neoplasm Metastasis (Metastasis) 12/2019 - 09/2005
5	Hyperplasia 10/2019 - 07/2002
4	Infections 08/2015 - 01/2004
4	Carcinoma in Situ 08/2007 - 07/2002
3	Acute Kidney Injury (Acute Renal Failure) 01/2022 - 03/2012
3	Nephrolithiasis 03/2012 - 09/2004
2	Chronic Renal Insufficiency 01/2018 - 03/2012
2	Lung Neoplasms (Lung Cancer) 01/2018 - 01/2013
2	Hyperuricemia 01/2018 - 01/2017
2	Gout 01/2017 - 01/2012
2	Renal Insufficiency (Renal Failure) 01/2017 - 06/2009
2	Transitional Cell Carcinoma 01/2016 - 07/2014
2	Metaplasia 05/2015 - 11/2005
2	Urinary Tract Infections (Urinary Tract Infection) 03/2012 - 05/2006
2	Hydronephrosis 06/2009 - 07/2004
2	Vesico-Ureteral Reflux (Vesicoureteral Reflux) 06/2009 - 07/2004
1	Sepsis (Septicemia) 01/2022
1	Adenocarcinoma of Lung 10/2019
1	Oncogene Addiction 01/2019
1	Fibrosis (Cirrhosis) 01/2018
1	Heart Diseases (Heart Disease) 01/2018
1	Hypertension (High Blood Pressure) 01/2018
1	Neoplastic Cell Transformation 01/2018
1	Colorectal Neoplasms (Colorectal Cancer) 01/2018
1	Oliguria 01/2017
1	Polyuria 01/2017

Drug/Important Bio-Agent (IBA)

17	Proteins (Proteins, Gene)FDA Link 12/2019 - 04/2002
10	UromodulinIBA 01/2022 - 04/2002
7	SmokeIBA 10/2019 - 02/2012
7	UroplakinsIBA 07/2009 - 07/2004
6	CarcinogensIBA 01/2020 - 05/2005
6	X-Linked Inhibitor of Apoptosis ProteinIBA 12/2019 - 05/2011
5	Biological ProductsIBA 01/2017 - 01/2003
5	Tumor Viral Antigens (Large T Antigen)IBA 11/2007 - 07/2002
4	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2022 - 07/2008
4	Phosphotransferases (Kinase)IBA 01/2019 - 02/2005
4	Biomarkers (Surrogate Marker)IBA 12/2015 - 05/2005
3	Pyruvate KinaseIBA 01/2022 - 04/2016
3	Messenger RNA (mRNA)IBA 12/2019 - 01/2018
3	NitrosaminesIBA 01/2018 - 05/2005
3	Cyclin D1IBA 06/2016 - 02/2005
3	ErbB Receptors (EGF Receptor)IBA 11/2014 - 07/2002
3	rho-Specific Guanine Nucleotide Dissociation InhibitorsIBA 04/2012 - 05/2011
3	NeuropilinsIBA 12/2010 - 07/2008
3	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 12/2010 - 07/2008
2	AldehydesIBA 01/2022 - 01/2018
2	EnzymesIBA 01/2021 - 05/2019
2	DNA (Deoxyribonucleic Acid)IBA 01/2020 - 01/2013
2	Small Interfering RNA (siRNA)IBA 12/2019 - 01/2017
2	Matrix Metalloproteinases (MMPs)IBA 12/2019 - 11/2017
2	hydroxide ionIBA 01/2018 - 05/2005
2	Transcription Factors (Transcription Factor)IBA 02/2017 - 01/2012
2	MicroRNAs (MicroRNA)IBA 01/2017 - 12/2015
2	Pharmaceutical PreparationsIBA 03/2016 - 01/2012
2	Type 3 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 3)IBA 01/2016 - 07/2011
2	Acrolein (Aqualin)IBA 10/2015 - 06/2014
2	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 05/2015 - 12/2009
2	LigandsIBA 05/2015 - 08/2008
2	Estrogen Receptor alphaIBA 09/2014 - 11/2005
2	Retinoblastoma ProteinIBA 12/2013 - 09/2005
2	LectinsIBA 11/2013 - 05/2006
2	isorhapontigeninIBA 08/2013 - 10/2012
2	CalciumIBA 07/2013 - 09/2010
2	Peptides (Polypeptides)IBA 12/2010 - 07/2008
2	NF-kappa B (NF-kB)IBA 02/2008 - 11/2007
2	OsteopontinIBA 12/2007 - 09/2004
2	Calcium OxalateIBA 12/2007 - 09/2004
2	Uroplakin IIIBA 11/2007 - 06/2006
1	ElectrolytesIBA 01/2022
1	Oncogene Proteins (Oncogene Protein)IBA 01/2022
1	Phenobarbital (Luminal)FDA Link 01/2020
1	MethyltransferasesIBA 01/2020
1	Apoptosis Regulatory ProteinsIBA 12/2019
1	Competitive Endogenous RNAIBA 06/2019
1	Histone Deacetylases (Histone Deacetylase)IBA 05/2019
1	tyrosine receptor (receptor, tyrosine)IBA 01/2019
1	Leucine-Rich Repeat ProteinsIBA 10/2018
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 10/2018
1	CollagenIBA 01/2018
1	KetonesIBA 01/2018
1	AngiotensinsIBA 01/2018
1	AldosteroneIBA 01/2018
1	NucleolinIBA 01/2018
1	Nicotine FDA Link 01/2018
1	Polycyclic Aromatic Hydrocarbons (Polynuclear Aromatic Hydrocarbons)IBA 01/2018
1	ReninIBA 01/2018
1	Inhibitor of Apoptosis ProteinsIBA 11/2017
1	CreatinineIBA 01/2017
1	Antineoplastic Agents (Antineoplastics)IBA 01/2017
1	HSP70 Heat-Shock Proteins (Heat-Shock Protein 70)IBA 01/2017
1	Cisplatin (Platino)FDA LinkGeneric 01/2017
1	shikoninIBA 01/2017
1	E2F1 Transcription FactorIBA 01/2017

Therapy/Procedure

10	Therapeutics 01/2022 - 09/2005
2	Cystectomy 11/2007 - 08/2007